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THE
LYMPHATIC SYSTEM
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Hot
was the earth, and restless too, with booming, blowing volcanoes
and tremulously trenching earthquakes. The conditions were not conducive
to sustain any form of life. The mixture of escaping gases contributed
to the formation of atmosphere around the earth. As the hot gases
rose higher & higher, they cooled & condensed to form clouds. The
hovering clouds gathered the electrical charges on their surfaces.
The piling opposite electrical charges attracted each other causing
lightening. With thunder -storms & cloud-bursts the torrential down
pour cooled the earth and formed the oceans. The striking thunder-bolt
in the medley of carbon, oxygen, hydrogen and nitrogen catalysed
to synthesize a new organic molecule, the protoplasm. Thus life
began on earth ! This conjecture of the scientists was later proved
in a laboratory experiment by Stanley Millar and Dr.Khare. In a
corked round-bottomed flask containing a mixture of carbon,oxygen,hydrogen
and nitrogen,they sparked on electric flash of high voltage. Result:The
specks of protoplasm were synthesized!. Life was born at the hands
of the sons of man!! The protoplasm was unstable. It needed protection.
The condensation of the protoplasm on the periphery provided the
needed protection in the form of cell-membrane and the condensation
in the center furnished the governing body, the nucleus. Thus an
omnipotent, unicellular organism came into being. The scientists
could not furnish the protoplasm these much needed facilities. Hence
they are unsuccessful to synthesise an omnipotent cell in the laboratory.
The ocean from without nurtured these unicellular organisms. They
excreted their waste products in the ocean. This transfer occurred
across the cell-membrane. As they evolved in the multicellular forms,
the deeper cells were deprived of nutrition and could not excrete
their waste. To overcome this difficulty, multiple intercommunicating
channels developed. Thus the primitive lymphatic system was developed.
As these multicellular animals evolved still further & formed an
external protective covering, the open-channel lymphatic system
became a closed lymphatic system.
At
the periphery i.e. in the tissue-spaces the lymphatic vessels begin
as microscopic closed-end or blind-end vessels, the lymphatic capillaries.
They are formed by single layer of endothelial cells supported by
the fibrous connective tissue. The capillaries join to form bigger
lymphatic vessels. They gradually become bigger and bigger & enter
the relay stations, the lymph nodes. The lymph circulates in the
lymph nodes. From here the second set of lymph vessels come out,
to be relayed to the second set of lymph nodes. All the lymph from
the body is ultimately collected into two big channels-the right
lymphatic duct & the left lymphatic duct (the thoracic duct). They
open in the right and left subclavian veins respectively. The thoracic
duct emerges from the receptaculum-Cisterna chyli. The cisterna
chyli is situated in the abdomen, in front of the second lumbar
vertebra. It receives lymph from both the lower limbs and from the
alimentary canal. Each lymph node is a bean-shaped body. It is lovered
by a thin capsule. From the capsule, the fibrous strands extend
into the lymph-node & divides the node into many compartment. The
lymph-node is divided into two zones, the outer cortex & the inner,
medulla. Each lymph node is a collection of lymphoid tissue. The
site on the surface of the lymph node at which the lymph vessels
enter and leave is marked by a dimple; known as the hilum. The lymphatics
entering the node are known as afferent-vessels and those leaving
the node are known as the efferent-vessels.
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PHYSIOLOGY
OF THE LYMPHATIC SYSTEM
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COMPOSITION
OF THE LYMPH: |
The
lymph contains 1) Water 94% 2)
Solids 6%
The lymph is rich in its protein content. The protein content varies
according to the region of the body from which the lymph is collected.
The lymph from the liver is richest in its protein content,that
from the intestines intermediate & that from the limbs poorest.
In the state of fasting the fat content of the lymph is very low.
After a fatty meal however the fat content may be very high. On
the average,the sugar content of the lymph is about 120 mg.per 100ml.
The other constituents of the lymph expressed in mgms per 100 ml
are: Urea 23.5 Non-protein nitrogenous substances 34.8 Creatimine
1.4 Chlorides 714 Phosphorus 11.8 Calcium 9.84 The lymph is rich
in various enzymes and antibodies When viewed under microscope it
contains a large number of white blood cells(W.B.C.S .), Mostly
the lympho cycles ranging from 500 to 75,000 per cu.mm.
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PROPERTIES
OF THE LYMPH: |
When
collected during fasting from the thoracic duct,the lymph is transparent,yellowish
in colour,faintly alkaline in reaction and clots slowly. Its colloidal
osmotic pressure is lower than tht of plasma but higher than that
of the tissue fluid. After a fatty meal the lymph appears milky due
to presence of droplets of emulsified fat absorbed from alimentary
canal. |
FUNCTIONS
OF THE LYMPH: |
1)
Nutritive : It supplies nutrition to those parts
of the body where the blood cannot reach. e.g.the cornea of the eye.
2) Oxygenation : It supplies to those structures
of the body where the blood vessels are absent. e.g. the cornea.
3)
Drainage : It drains away the exess of tissue fluid
& the metabolites.
4)
Homeostasis : It maintains the volume & the composition of tissue
fluid.
5)
It returns the proteins to the blood from the tissue spaces.
6) Fats from intestine are absorbed through the lymphatics .
7) Defensive : The lymphocytes & the monocytes of the lymph
are the defensive cells of the body. The lymphatics also remove bacteria
from the tissues.
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1)
They act as a relay station for the circulating lymph. 2) They act as a
filter ; entrapping the particles of carbon , poisonous compounds of such
heavy metals like mercury, arsenic, bismuth etc. 3) They produce lymphocytes
which furnishes the defensive force not only locally but also in the blood.
The lymphocytes devour the bacteria (phagocytosis ) , foreign particles.
The lymphnodes an important role against bacterial infection. 4) The lymph
nodes also entrap cancer cells &protect our body against the spread of cancer.
5) They synthesize g- globulins .The g- globulins are the chemicals, which
fight against diseases. 6) They set in motion an immunological response.
They help to synthesise various antibodies. This response is necessary for
the development of immunity of our body against a large variety of diseases.
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